Electrophile-Modified Lipoic Derivatives of PDC-E2 Elicits Anti-mitochondrial Antibody Reactivity

Our laboratory has hypothesized that xenobiotic modification of the native lipoyl moiety of the major mitochondrial autoantigen, the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2), may lead to loss of self-tolerance in primary biliary cirrhosis (PBC). This thesis is based on the finding o...

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Hauptverfasser: Naiyanetr, Phornnop, Butler, Jeffrey D., Meng, Liping, Pfeiff, Janice, Kenny, Thomas P., Guggenheim, Kathryn G., Reiger, Roman, Lam, Kit, Kurth, Mark J., Ansari, Aftab. A., Coppel, Ross L., López-Hoyos, Marcos, Gershwin, M. Eric, Leung, Patrick S.C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206141/
https://ncbi.nlm.nih.gov/pubmed/21763105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2011.06.001
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