AMA Heterogeneity and the Xenobiotic Etiology of Primary Biliary Cirrhosis

Antimitochondrial antibodies (AMA) directed against the lipoyl domain of the E2 subunit of pyruvate dehydrogenase (PDC-E2) are detected in 95% of patients with PBC and are present before onset of clinical disease. The recent demonstration that AMA recognize xenobiotic modified PDC-E2 with higher tit...

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Detalhes bibliográficos
Main Authors: Chen, Richy C.Y., Naiyanetr, Phornnop, Shu, Shang-An, Wang, Jinjun, Yang, Guo-Xiang, Thomas, P. Kenny, Guggenheim, Kathryn C., Butler, Jeffrey D., Bowlus, Christopher, Tao, Mi-Hua, Kurth, Mark J., Ansari, Aftab A., Kaplan, Marshall, Coppel, Ross L., Lleo, Ana, Gershwin, M. Eric, Leung, Patrick S.C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601563/
https://ncbi.nlm.nih.gov/pubmed/23184636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26157
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