Identification of Hepatic Niche Harboring Human Acute Lymphoblastic Leukemic Cells via the SDF-1/CXCR4 Axis

In acute lymphoblastic leukemia (ALL) patients, the bone marrow niche is widely known to be an important element of treatment response and relapse. Furthermore, a characteristic liver pathology observed in ALL patients implies that the hepatic microenvironment provides an extramedullary niche for le...

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Main Authors: Kato, Itaru, Niwa, Akira, Heike, Toshio, Fujino, Hisanori, Saito, Megumu K., Umeda, Katsutsugu, Hiramatsu, Hidefumi, Ito, Mamoru, Morita, Makiko, Nishinaka, Yoko, Adachi, Souichi, Ishikawa, Fumihiko, Nakahata, Tatsutoshi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206061/
https://ncbi.nlm.nih.gov/pubmed/22069486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027042
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