Direct Delivery of piggyBac CD19 CAR T Cells Has Potent Anti-tumor Activity against ALL Cells in CNS in a Xenograft Mouse Model

The anti-CD19 chimeric antigen receptor (CAR) T cells showed excellent effect against acute lymphoblastic leukemia (ALL) in bone marrow (BM) in clinical trials. However, it remains to be elucidated whether the CD19 CAR T cell therapy is effective for ALL cells in central nervous system (CNS) because...

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Gepubliceerd in:Mol Ther Oncolytics
Hoofdauteurs: Tanaka, Kuniaki, Kato, Itaru, Tanaka, Miyuki, Morita, Daisuke, Matsuda, Kazuyuki, Takahashi, Yoshiyuki, Nakahata, Tatsutoshi, Umeda, Katsutsugu, Hiramatsu, Hidefumi, Adachi, Souichi, Takita, Junko, Nakazawa, Yozo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Gene & Cell Therapy 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321814/
https://ncbi.nlm.nih.gov/pubmed/32637579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.05.013
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