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Selective Synthesis of Hydroxy Analogues of Valinomycin using Dioxiranes

[Image: see text] A synthesis of representative monohydroxy derivatives of valinomycin (VLM) was achieved under mild conditions by direct hydroxylation at the side-chains of the macrocyclic substrate using dioxiranes. Results demonstrate that the powerful methyl(trifluoromethyl)dioxirane 1b should b...

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Détails bibliographiques
Auteurs principaux: Annese, Cosimo, Fanizza, Immacolata, Calvano, Cosima D., D’Accolti, Lucia, Fusco, Caterina, Curci, Ruggero, Williard, Paul G.
Format: Artigo
Langue:Inglês
Publié: 2011
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205966/
https://ncbi.nlm.nih.gov/pubmed/21905749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol201971v
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