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The Correlation between Multidomain Enzymes and Mutiple Activation Mechanisms – The Case of Phospholipase Cβ and its Membrane Interactions
Phospholipase Cβ2 (PLCβ2) is a large, multidomain enzyme that catalyzes the hydrolysis of the signaling lipid phosphoinositol 4,5 bisphosphate (PIP(2)) to promote mitogenic and proliferative changes in the cell. PLCβ2 is activated by Gα and Gβγ subunits of heterotrimeric G proteins, as well as small...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3205958/ https://ncbi.nlm.nih.gov/pubmed/21906583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2011.08.028 |
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