Axonal Localization of Transgene mRNA in Mature PNS and CNS Neurons

Axonal mRNA transport is robust in cultured neurons but there has been limited evidence for this in vivo. We have used a genetic approach to test for in vivo axonal transport of reporter mRNAs. We show that β-actin's 3′-UTR can drive axonal localization of GFP mRNA in mature DRG neurons, but mi...

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Detalhes bibliográficos
Main Authors: Willis, Dianna E., Xu, Mei, Donnelly, Christopher J., Tep, Chhavy, Kendall, Marvin, Erenstheyn, Marina, English, Arthur W., Schanen, N. Carolyn, Kirn-Safran, Catherine B., Yoon, Sung Ok, Bassell, Gary J., Twiss, Jeffery L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205917/
https://ncbi.nlm.nih.gov/pubmed/21994364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2950-11.2011
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