Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity

Subcellular localization of mRNAs is regulated by RNA–protein interactions. Here, we show that introduction of a reporter mRNA with the 3′UTR of β-actin mRNA competes with endogenous mRNAs for binding to ZBP1 in adult sensory neurons. ZBP1 is needed for axonal localization of β-actin mRNA, and intro...

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Detalhes bibliográficos
Main Authors: Donnelly, Christopher J, Willis, Dianna E, Xu, Mei, Tep, Chhavy, Jiang, Chunsu, Yoo, Soonmoon, Schanen, N Carolyn, Kirn-Safran, Catherine B, van Minnen, Jan, English, Arthur, Yoon, Sung Ok, Bassell, Gary J, Twiss, Jeffery L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243598/
https://ncbi.nlm.nih.gov/pubmed/21964071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.347
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