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The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1

In response to stimulation with proinflammatory cytokines, the deubiquitinase A20 inducibly interacts with the regulatory molecules TAX1BP1, Itch and RNF11 to form the A20 ubiquitin-editing complex. However, the molecular signal that coordinates the assembly of this complex has remained elusive. Her...

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Bibliografiske detaljer
Main Authors: Shembade, Noula, Pujari, Rajeshree, Harhaj, Nicole S, Abbott, Derek W, Harhaj, Edward W
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205447/
https://ncbi.nlm.nih.gov/pubmed/21765415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2066
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