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Human T Cell Leukemia Virus Type 1 Tax Inhibits Innate Antiviral Signaling via NF-κB-Dependent Induction of SOCS1

Human T cell leukemia virus type 1 (HTLV-1) inhibits host antiviral signaling pathways although the underlying mechanisms are unclear. Here we found that the HTLV-1 Tax oncoprotein induced the expression of SOCS1, an inhibitor of interferon signaling. Tax required NF-κB, but not CREB, to induce the...

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Bibliografische gegevens
Hoofdauteurs: Charoenthongtrakul, Soratree, Zhou, Qinjie, Shembade, Noula, Harhaj, Nicole S., Harhaj, Edward W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126571/
https://ncbi.nlm.nih.gov/pubmed/21593151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00007-11
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