Effect of the ILE86TER mutation in the γ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signalling

The light-dependent decrease in cyclic guanosine monophosphate (cGMP) in the rod outer segment is produced by a phosphodiesterase (PDE6), consisting of catalytic α and β subunits and two inhibitory γ subunits. The molecular mechanism of PDE6γ regulation of the catalytic subunits is uncertain. To stu...

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Bibliographische Detailangaben
Hauptverfasser: Tsang, Stephen H., Woodruff, Michael L., Lin, Chyuan-Sheng, Jacobson, Barry D., Naumann, Matthew C., Hsu, Chun Wei, Davis, Richard J., Cilluffo, Marianne C., Chen, Jeannie, Fain, Gordon L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205198/
https://ncbi.nlm.nih.gov/pubmed/21920434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2011.08.021
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