Functional Rescue of Degenerating Photoreceptors in Mice Homozygous for a Hypomorphic cGMP Phosphodiesterase 6 b Allele (Pde6b(H620Q))

PURPOSE: Approximately 8% of autosomal recessive retinitis pigmentosa (RP) cases worldwide are due to defects in rod-specific phosphodiesterase PDE6, a tetramer consisting of catalytic (PDE6α and PDE6β) and two regulatory (PDE6γ) subunits. In mice homozygous for a nonsense Pde6b(rd1) allele, absence...

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主要な著者: Davis, Richard J., Tosi, Joaquin, Janisch, Kerstin M., Kasanuki, J. Mie, Wang, Nan-Kai, Kong, Jian, Tsui, Ilene, Cilluffo, Marianne, Woodruff, Michael L., Fain, Gordon L., Lin, Chyuan-Sheng, Tsang, Stephen H.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715364/
https://ncbi.nlm.nih.gov/pubmed/18658088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.07-1422
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