piRNA production requires heterochromatin formation in Drosophila

Protecting the genome from transposable element (TE) mobilization is critical for germline development. In Drosophila, Piwi proteins and their bound small RNAs (piRNAs) provide a potent defense against TE activity. TE targeting piRNAs are processed from TE-dense heterochromatic loci termed ‘piRNA cl...

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Bibliografiske detaljer
Main Authors: Rangan, Prashanth, Malone, Colin D., Navarro, Caryn, Newbold, Sam P., Hayes, Patrick S., Sachidanandam, Ravi, Hannon, Gregory J., Lehmann, Ruth
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205116/
https://ncbi.nlm.nih.gov/pubmed/21820311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2011.06.057
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