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Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells

Recent research implicates soluble aggregated forms of α-synuclein as neurotoxic species with a central role in the pathogenesis of Parkinson's disease and related disorders. The pathway by which α-synuclein aggregates is believed to follow a step-wise pattern, in which dimers and smaller oligo...

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Hlavní autoři: Näsström, Thomas, Gonçalves, Susana, Sahlin, Charlotte, Nordström, Eva, Screpanti Sundquist, Valentina, Lannfelt, Lars, Bergström, Joakim, Outeiro, Tiago F., Ingelsson, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205056/
https://ncbi.nlm.nih.gov/pubmed/22073131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027230
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