MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice

Mutations in human FYVE, RhoGEF, and PH domain–containing 1 (FGD1) cause faciogenital dysplasia (FGDY; also known as Aarskog syndrome), an X-linked disorder that affects multiple skeletal structures. FGD1 encodes a guanine nucleotide exchange factor (GEF) that specifically activates the Rho GTPase C...

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Autors principals: Zou, Weiguo, Greenblatt, Matthew B., Shim, Jae-Hyuck, Kant, Shashi, Zhai, Bo, Lotinun, Sutada, Brady, Nicholas, Hu, Dorothy Zhang, Gygi, Steven P., Baron, Roland, Davis, Roger J., Jones, Dallas, Glimcher, Laurie H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204846/
https://ncbi.nlm.nih.gov/pubmed/21965325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59041
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