Depletion of CD4(+) T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques

CD4(+) T cells play a central role in the immunopathogenesis of HIV/AIDS, and their depletion during chronic HIV infection is a hallmark of disease progression. However, the relative contribution of CD4(+) T cells as mediators of antiviral immune responses and targets for virus replication is still...

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Hlavní autoři: Ortiz, Alexandra M., Klatt, Nichole R., Li, Bing, Yi, Yanjie, Tabb, Brian, Hao, Xing Pei, Sternberg, Lawrence, Lawson, Benton, Carnathan, Paul M., Cramer, Elizabeth M., Engram, Jessica C., Little, Dawn M., Ryzhova, Elena, Gonzalez-Scarano, Francisco, Paiardini, Mirko, Ansari, Aftab A., Ratcliffe, Sarah, Else, James G., Brenchley, Jason M., Collman, Ronald G., Estes, Jacob D., Derdeyn, Cynthia A., Silvestri, Guido
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204830/
https://ncbi.nlm.nih.gov/pubmed/22005304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46023
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