A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies

The tetraspanin CD37 is widely expressed in B-cell malignancies and represents an attractive target for immunotherapy with mAbs. We have chimerized a high-affinity mouse Ab to CD37 and engineered the CH2 domain for improved binding to human Fcγ receptors. The resulting mAb 37.1 showed high intrinsic...

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Hlavní autoři: Heider, Karl-Heinz, Kiefer, Kerstin, Zenz, Thorsten, Volden, Matthias, Stilgenbauer, Stephan, Ostermann, Elinborg, Baum, Anke, Lamche, Herbert, Küpcü, Zaruhi, Jacobi, Alexander, Müller, Steffen, Hirt, Ulrich, Adolf, Günther R., Borges, Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2011
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204733/
https://ncbi.nlm.nih.gov/pubmed/21795744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-351932
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