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Total Synthesis of α-1C-Galactosylceramide, an Immunostimulatory C-Glycosphingolipid, and Confirmation of the Stereochemistry in the First-Generation Synthesis

[Image: see text] A non-isosteric α-C-glycoside analogue of KRN7000 (α-1C-GalCer, 1) was reported to induce a selective type of cytokine release in human invariant natural killer cells in vitro. We report here a very concise synthetic route to 1 and its analogue 1′. The key steps include olefin cros...

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Bibliografiske detaljer
Main Authors: Liu, Zheng, Byun, Hoe-Sup, Bittman, Robert
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204185/
https://ncbi.nlm.nih.gov/pubmed/21958232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo201450s
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