Protease-Activated Receptor 1 and Hematopoietic Cell Tissue Factor Are Required for Hepatic Steatosis in Mice Fed a Western Diet

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and metabolic syndrome and contributes to increased risk of cardiovascular disease and liver-related morbidity and mortality. Indeed, obese patients with metabolic syndrome generate greater amounts of thrombin, an indic...

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Main Authors: Kassel, Karen M., Owens, A. Phillip, Rockwell, Cheryl E., Sullivan, Bradley P., Wang, Ruipeng, Tawfik, Ossama, Li, Guodong, Guo, Grace L., Mackman, Nigel, Luyendyk, James P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2011
Teme:
Regular Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204032/
https://ncbi.nlm.nih.gov/pubmed/21907177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.07.015
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