Acid Sphingomyelinase Gene Deficiency Ameliorates the Hyperhomocysteinemia-Induced Glomerular Injury in Mice

Hyperhomocysteinemia (hHcys) enhances ceramide production, leading to the activation of NADPH oxidase and consequent glomerular oxidative stress and sclerosis. The present study was performed to determine whether acid sphingomyelinase (Asm), a ceramide-producing enzyme, is implicated in the developm...

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Autors principals: Boini, Krishna M., Xia, Min, Li, Caixia, Zhang, Chun, Payne, Lori P., Abais, Justine M., Poklis, Justin L., Hylemon, Philip B., Li, Pin-Lan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2011
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204029/
https://ncbi.nlm.nih.gov/pubmed/21893018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.07.019
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