Acid Sphingomyelinase Gene Deficiency Ameliorates the Hyperhomocysteinemia-Induced Glomerular Injury in Mice

Hyperhomocysteinemia (hHcys) enhances ceramide production, leading to the activation of NADPH oxidase and consequent glomerular oxidative stress and sclerosis. The present study was performed to determine whether acid sphingomyelinase (Asm), a ceramide-producing enzyme, is implicated in the developm...

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Detalhes bibliográficos
Main Authors: Boini, Krishna M., Xia, Min, Li, Caixia, Zhang, Chun, Payne, Lori P., Abais, Justine M., Poklis, Justin L., Hylemon, Philip B., Li, Pin-Lan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204029/
https://ncbi.nlm.nih.gov/pubmed/21893018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.07.019
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