Differential Sensitivity of ERBB2 Kinase Domain Mutations towards Lapatinib

BACKGROUND: Overexpression of the ERBB2 kinase is observed in about one-third of breast cancer patients and the dual ERBB1/ERBB2 kinase inhibitor lapatinib was recently approved for the treatment of advanced ERBB2-positive breast cancer. Mutations in the ERBB2 receptor have recently been reported in...

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Bibliographic Details
Main Authors: Kancha, Rama Krishna, von Bubnoff, Nikolas, Bartosch, Natalie, Peschel, Christian, Engh, Richard A., Duyster, Justus
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203921/
https://ncbi.nlm.nih.gov/pubmed/22046346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026760
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