Differentiation of the open and closed states of the ionic channels of nicotinic acetylcholine receptors by tricyclic antidepressants.

The actions of two clinically important dibenzocycloheptane antidepressant drugs, amitriptyline and nortriptyline, were studied on ionic channels of nicotinic acetylcholine (AcCho) receptors at the neuromuscular junction of frog skeletal muscle. Amitriptyline (5-10 microM) and nortriptyline (1-2 mic...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Schofield, G G, Witkop, B, Warnick, J E, Albuquerque, E X
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1981
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC320386/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6272297/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.8.5240
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