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Differentiation of the open and closed states of the ionic channels of nicotinic acetylcholine receptors by tricyclic antidepressants.

The actions of two clinically important dibenzocycloheptane antidepressant drugs, amitriptyline and nortriptyline, were studied on ionic channels of nicotinic acetylcholine (AcCho) receptors at the neuromuscular junction of frog skeletal muscle. Amitriptyline (5-10 microM) and nortriptyline (1-2 mic...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Schofield, G G, Witkop, B, Warnick, J E, Albuquerque, E X
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1981
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC320386/
https://ncbi.nlm.nih.gov/pubmed/6272297
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