Differentiation of the open and closed states of the ionic channels of nicotinic acetylcholine receptors by tricyclic antidepressants.

The actions of two clinically important dibenzocycloheptane antidepressant drugs, amitriptyline and nortriptyline, were studied on ionic channels of nicotinic acetylcholine (AcCho) receptors at the neuromuscular junction of frog skeletal muscle. Amitriptyline (5-10 microM) and nortriptyline (1-2 mic...

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Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Schofield, G G, Witkop, B, Warnick, J E, Albuquerque, E X
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1981
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC320386/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6272297/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.8.5240
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