Differentiation of the open and closed states of the ionic channels of nicotinic acetylcholine receptors by tricyclic antidepressants.

The actions of two clinically important dibenzocycloheptane antidepressant drugs, amitriptyline and nortriptyline, were studied on ionic channels of nicotinic acetylcholine (AcCho) receptors at the neuromuscular junction of frog skeletal muscle. Amitriptyline (5-10 microM) and nortriptyline (1-2 mic...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Schofield, G G, Witkop, B, Warnick, J E, Albuquerque, E X
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1981
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC320386/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6272297/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.8.5240
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