Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91

Stim and Orai proteins comprise the molecular machinery of Ca(2+) release-activated Ca(2+) (CRAC) channels. As an approach toward understanding the gating of Orai1 channels, we investigated effects of selected mutations at two conserved sites in the first transmembrane segment (TM1): arginine 91 loc...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhang, Shenyuan L., Yeromin, Andriy V., Hu, Junjie, Amcheslavsky, Anna, Zheng, Hongying, Cahalan, Michael D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203763/
https://ncbi.nlm.nih.gov/pubmed/21987804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114821108
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