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Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy

To deal with the constant challenge of protein misfolding in the endoplasmic reticulum (ER), eukaryotic cells have evolved an ER protein quality control (ERQC) mechanism that is integrated with an adaptive stress response. The ERQC pathway is comprised of factors residing in the ER lumen that functi...

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Detalles Bibliográficos
Main Authors: Liu, Yanfen, Ye, Yihong
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203708/
https://ncbi.nlm.nih.gov/pubmed/21537343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.75
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