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Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy
To deal with the constant challenge of protein misfolding in the endoplasmic reticulum (ER), eukaryotic cells have evolved an ER protein quality control (ERQC) mechanism that is integrated with an adaptive stress response. The ERQC pathway is comprised of factors residing in the ER lumen that functi...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3203708/ https://ncbi.nlm.nih.gov/pubmed/21537343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.75 |
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