3′-Deoxy-3′-[(18)F]Fluorothymidine Positron Emission Tomography Is a Sensitive Method for Imaging the Response of BRAF-Dependent Tumors to MEK Inhibition

Activating mutations of BRAF occur in ~7% of all human tumors and in the majority of melanomas. These tumors are very sensitive to pharmacologic inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), which causes loss of D-cyclin expression, hypophosphoryl...

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Detaylı Bibliyografya
Asıl Yazarlar: Solit, David B., Santos, Elmer, Pratilas, Christine A., Lobo, Jose, Moroz, Maxim, Cai, Shangde, Blasberg, Ronald, Sebolt-Leopold, Judith, Larson, Steven, Rosen, Neal
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203690/
https://ncbi.nlm.nih.gov/pubmed/18056475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-2976
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