3′-Deoxy-3′-[(18)F]Fluorothymidine Positron Emission Tomography Is a Sensitive Method for Imaging the Response of BRAF-Dependent Tumors to MEK Inhibition

Activating mutations of BRAF occur in ~7% of all human tumors and in the majority of melanomas. These tumors are very sensitive to pharmacologic inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), which causes loss of D-cyclin expression, hypophosphoryl...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Solit, David B., Santos, Elmer, Pratilas, Christine A., Lobo, Jose, Moroz, Maxim, Cai, Shangde, Blasberg, Ronald, Sebolt-Leopold, Judith, Larson, Steven, Rosen, Neal
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203690/
https://ncbi.nlm.nih.gov/pubmed/18056475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-2976
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados