Reprogramming of ovine adult fibroblasts to pluripotency via drug-inducible expression of defined factors

Reprogramming of somatic cells in the enucleated egg made Dolly, the sheep, the first successfully cloned mammal in 1996. However, the mechanism of sheep somatic cell reprogramming has not yet been addressed. Moreover, sheep embryonic stem (ES) cells are still not available, which limits the generat...

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Autori principali: Bao, Lei, He, Lixiazi, Chen, Jijun, Wu, Zhao, Liao, Jing, Rao, Lingjun, Ren, Jiangtao, Li, Hui, Zhu, Hui, Qian, Lei, Gu, Yijun, Dai, Huimin, Xu, Xun, Zhou, Jinqiu, Wang, Wen, Cui, Chun, Xiao, Lei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203662/
https://ncbi.nlm.nih.gov/pubmed/21221129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.6
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