Quaternary structure of the specific p53–DNA complex reveals the mechanism of p53 mutant dominance

The p53 tumour suppressor is a transcriptional activator that controls cell fate in response to various stresses. p53 can initiate cell cycle arrest, senescence and/or apoptosis via transactivation of p53 target genes, thus preventing cancer onset. Mutations that impair p53 usually occur in the core...

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Bibliographic Details
Main Authors: Aramayo, Ricardo, Sherman, Michael B., Brownless, Kathryne, Lurz, Rudi, Okorokov, Andrei L., Orlova, Elena V.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203597/
https://ncbi.nlm.nih.gov/pubmed/21764777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr386
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