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Quaternary structure of the specific p53–DNA complex reveals the mechanism of p53 mutant dominance
The p53 tumour suppressor is a transcriptional activator that controls cell fate in response to various stresses. p53 can initiate cell cycle arrest, senescence and/or apoptosis via transactivation of p53 target genes, thus preventing cancer onset. Mutations that impair p53 usually occur in the core...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3203597/ https://ncbi.nlm.nih.gov/pubmed/21764777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr386 |
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