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C-Raf is required for the initiation of lung cancer by K-Ras(G12D)
The Ras/Raf/MEK/ERK pathway is primarily responsible for mitogenesis in metazoans, and mutational activation of this pathway is common in cancer. A variety of selective chemical inhibitors directed against the MAPK pathway are now available for clinical investigation and thus the determination of th...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3203527/ https://ncbi.nlm.nih.gov/pubmed/22043453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-10-0044 |
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