The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

BACKGROUND: GP-BAR1, a member G protein coupled receptor superfamily, is a cell surface bile acid-activated receptor highly expressed in the ileum and colon. In monocytes, ligation of GP-BAR1 by secondary bile acids results in a cAMP-dependent attenuation of cytokine generation. AIMS: To investigate...

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Hauptverfasser: Cipriani, Sabrina, Mencarelli, Andrea, Chini, Maria Giovanna, Distrutti, Eleonora, Renga, Barbara, Bifulco, Giuseppe, Baldelli, Franco, Donini, Annibale, Fiorucci, Stefano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203117/
https://ncbi.nlm.nih.gov/pubmed/22046243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025637
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