Re-Assembled Botulinum Neurotoxin Inhibits CNS Functions without Systemic Toxicity

The therapeutic potential of botulinum neurotoxin type A (BoNT/A) has recently been widely recognized. BoNT/A acts to silence synaptic transmission via specific proteolytic cleavage of an essential neuronal protein, SNAP25. The advantages of BoNT/A-mediated synaptic silencing include very long durat...

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Hlavní autoři: Ferrari, Enrico, Maywood, Elizabeth S., Restani, Laura, Caleo, Matteo, Pirazzini, Marco, Rossetto, Ornella, Hastings, Michael H., Niranjan, Dhevahi, Schiavo, Giampietro, Davletov, Bazbek
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202830/
https://ncbi.nlm.nih.gov/pubmed/22069712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins3040345
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