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Re-Assembled Botulinum Neurotoxin Inhibits CNS Functions without Systemic Toxicity
The therapeutic potential of botulinum neurotoxin type A (BoNT/A) has recently been widely recognized. BoNT/A acts to silence synaptic transmission via specific proteolytic cleavage of an essential neuronal protein, SNAP25. The advantages of BoNT/A-mediated synaptic silencing include very long durat...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3202830/ https://ncbi.nlm.nih.gov/pubmed/22069712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins3040345 |
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