A proton gradient controls a calcium-release channel in sarcoplasmic reticulum.
Sarcoplasmic reticulum vesicles from mammalian skeletal muscle have previously been shown to develop a proton gradient (alkaline inside) of 0.15-0.5 pH units during active Ca2+ uptake. We found that dissipation of this gradient by the proton ionophores gramicidin, nigericin, and carbonyl cyanide p-t...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1981
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC320264/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6272276/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.8.4828 |
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