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A proton gradient controls a calcium-release channel in sarcoplasmic reticulum.

Sarcoplasmic reticulum vesicles from mammalian skeletal muscle have previously been shown to develop a proton gradient (alkaline inside) of 0.15-0.5 pH units during active Ca2+ uptake. We found that dissipation of this gradient by the proton ionophores gramicidin, nigericin, and carbonyl cyanide p-t...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Shoshan, V, MacLennan, D H, Wood, D S
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC320264/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6272276/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.8.4828
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