Pyruvate Kinase Triggers a Metabolic Feedback Loop that Controls Redox Metabolism in Respiring Cells

In proliferating cells, a transition from aerobic to anaerobic metabolism is known as the Warburg effect, whose reversal inhibits cancer cell proliferation. Studying its regulator pyruvate kinase (PYK) in yeast, we discovered that central metabolism is self-adapting to synchronize redox metabolism w...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Grüning, Nana-Maria, Rinnerthaler, Mark, Bluemlein, Katharina, Mülleder, Michael, Wamelink, Mirjam M.C., Lehrach, Hans, Jakobs, Cornelis, Breitenbach, Michael, Ralser, Markus
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cell Press 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202625/
https://ncbi.nlm.nih.gov/pubmed/21907146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.06.017
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