P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis

Clinical studies show that estrogen receptor-α (ER) expressing tumors tend to have better prognosis, respond to antiestrogen therapy and have wild-type p53. Conversely, tumors with inactivating mutations in p53 tend to have worse outcomes and to be ER-negative and unresponsive to antihormone treatme...

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Autori principali: Fuchs-Young, Robin, Shirley, Stephanie H., Lambertz, Isabel, Colby, Jennifer K. L., Tian, Jie, Johnston, Dennis, Gimenez-Conti, Irma B., Donehower, Lawrence A., Conti, Claudio J., Hursting, Stephen D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202603/
https://ncbi.nlm.nih.gov/pubmed/21191649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-010-1308-y
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