Nebulisation of Receptor-Targeted Nanocomplexes for Gene Delivery to the Airway Epithelium

BACKGROUND: Gene therapy mediated by synthetic vectors may provide opportunities for new treatments for cystic fibrosis (CF) via aerosolisation. Vectors for CF must transfect the airway epithelium efficiently and not cause inflammation so they are suitable for repeated dosing. The inhaled aerosol sh...

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Hauptverfasser: Manunta, Maria D. I., McAnulty, Robin J., Tagalakis, Aristides D., Bottoms, Stephen E., Campbell, Frederick, Hailes, Helen C., Tabor, Alethea B., Laurent, Geoffrey J., O'Callaghan, Christopher, Hart, Stephen L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202583/
https://ncbi.nlm.nih.gov/pubmed/22046351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026768
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