Nebulisation of Receptor-Targeted Nanocomplexes for Gene Delivery to the Airway Epithelium

BACKGROUND: Gene therapy mediated by synthetic vectors may provide opportunities for new treatments for cystic fibrosis (CF) via aerosolisation. Vectors for CF must transfect the airway epithelium efficiently and not cause inflammation so they are suitable for repeated dosing. The inhaled aerosol sh...

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Detalhes bibliográficos
Main Authors: Manunta, Maria D. I., McAnulty, Robin J., Tagalakis, Aristides D., Bottoms, Stephen E., Campbell, Frederick, Hailes, Helen C., Tabor, Alethea B., Laurent, Geoffrey J., O'Callaghan, Christopher, Hart, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202583/
https://ncbi.nlm.nih.gov/pubmed/22046351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026768
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