The Antiemetic 5-HT(3) Receptor Antagonist Palonosetron Inhibits Substance P-Mediated Responses In Vitro and In Vivo()

Palonosetron is the only 5-HT(3) receptor antagonist approved for the treatment of delayed chemotherapy-induced nausea and vomiting (CINV) in moderately emetogenic chemotherapy. Accumulating evidence suggests that substance P (SP), the endogenous ligand acting preferentially on neurokinin-1 (NK-1) r...

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Autori principali: Rojas, Camilo, Li, Ying, Zhang, Jie, Stathis, Marigo, Alt, Jesse, Thomas, Ajit G., Cantoreggi, Sergio, Sebastiani, Silvia, Pietra, Claudio, Slusher, Barbara S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Pharmacology and Experimental Therapeutics 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202469/
https://ncbi.nlm.nih.gov/pubmed/20724484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.166181
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