Knock-in Mouse Model for Resistance to Thyroid Hormone (RTH): An RTH Mutation in the Thyroid Hormone Receptor Beta Gene Disrupts Cochlear Morphogenesis

Thyroid hormone and the beta isoform of its receptor, Trb, are essential for normal development of the mammalian auditory system. We have analyzed auditory system function and structure in a mouse strain with a targeted Thrb mutation, ThrbPV, which leads to the loss of binding of thyroid hormone (T3...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Griffith, Andrew J., Szymko, Yvonne M., Kaneshige, Masahiro, Quiñónez, Rafael E., Kaneshige, Kumiko, Heintz, Kasey A., Mastroianni, Mary Ann, Kelley, Matthew W., Cheng, Sheue-yann
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer-Verlag 2002
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202409/
https://ncbi.nlm.nih.gov/pubmed/12382103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s101620010092
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