Knock-in Mouse Model for Resistance to Thyroid Hormone (RTH): An RTH Mutation in the Thyroid Hormone Receptor Beta Gene Disrupts Cochlear Morphogenesis

Thyroid hormone and the beta isoform of its receptor, Trb, are essential for normal development of the mammalian auditory system. We have analyzed auditory system function and structure in a mouse strain with a targeted Thrb mutation, ThrbPV, which leads to the loss of binding of thyroid hormone (T3...

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Main Authors: Griffith, Andrew J., Szymko, Yvonne M., Kaneshige, Masahiro, Quiñónez, Rafael E., Kaneshige, Kumiko, Heintz, Kasey A., Mastroianni, Mary Ann, Kelley, Matthew W., Cheng, Sheue-yann
Format: Artigo
Sprog:Inglês
Udgivet: Springer-Verlag 2002
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202409/
https://ncbi.nlm.nih.gov/pubmed/12382103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s101620010092
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