The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

Aberrant DNA methylation is often associated with cancer and the formation of tumors; however, the underlying mechanisms, in particular the recruitment and regulation of DNA methyltransferases remain largely unknown. In this study, we identified USP7 as an interaction partner of Dnmt1 and UHRF1 in v...

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Hlavní autoři: Felle, Max, Joppien, Saskia, Németh, Attila, Diermeier, Sarah, Thalhammer, Verena, Dobner, Thomas, Kremmer, Elisabeth, Kappler, Roland, Längst, Gernot
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
Gene Regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201865/
https://ncbi.nlm.nih.gov/pubmed/21745816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr528
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