RNAs synthesized using photocleavable biotinylated nucleotides have dramatically improved catalytic efficiency

Obtaining homogeneous population of natively folded RNAs is a crippling problem encountered when preparing RNAs for structural or enzymatic studies. Most of the traditional methods that are employed to prepare large quantities of RNAs involve procedures that partially denature the RNA. Here, we pres...

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Bibliographic Details
Main Authors: Luo, Yiling, Eldho, Nadukkudy V., Sintim, Herman O., Dayie, T. Kwaku
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201860/
https://ncbi.nlm.nih.gov/pubmed/21742763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr464
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