Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

BACKGROUND: The full complement of DNA mutations that are responsible for the pathogenesis of acute myeloid leukemia (AML) is not yet known. METHODS: We used massively parallel DNA sequencing to obtain a very high level of coverage (approximately 98%) of a primary, cytogenetically normal, de novo ge...

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Detalhes bibliográficos
Main Authors: Mardis, Elaine R., Ding, Li, Dooling, David J., Larson, David E., McLellan, Michael D., Chen, Ken, Koboldt, Daniel C., Fulton, Robert S., Delehaunty, Kim D., McGrath, Sean D., Fulton, Lucinda A., Locke, Devin P., Magrini, Vincent J., Abbott, Rachel M., Vickery, Tammi L., Reed, Jerry S., Robinson, Jody S., Wylie, Todd, Smith, Scott M., Carmichael, Lynn, Eldred, James M., Harris, Christopher C., Walker, Jason, Peck, Joshua B., Du, Feiyu, Dukes, Adam F., Sanderson, Gabriel E., Brummett, Anthony M., Clark, Eric, McMichael, Joshua F., Meyer, Rick J., Schindler, Jonathan K., Pohl, Craig S., Wallis, John W., Shi, Xiaoqi, Lin, Ling, Schmidt, Heather, Tang, Yuzhu, Haipek, Carrie, Wiechert, Madeline E., Ivy, Jolynda V., Kalicki, Joelle, Elliott, Glendoria, Ries, Rhonda E., Payton, Jacqueline E., Westervelt, Peter, Tomasson, Michael H., Watson, Mark A., Baty, Jack, Heath, Sharon, Shannon, William D., Nagarajan, Rakesh, Link, Daniel C., Walter, Matthew J., Graubert, Timothy A., DiPersio, John F., Wilson, Richard K., Ley, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201812/
https://ncbi.nlm.nih.gov/pubmed/19657110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa0903840
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