Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated

The initial antibody response to HIV-1 is targeted to envelope (Env) gp41, and is nonneutralizing and ineffective in controlling viremia. To understand the origins and characteristics of gp41-binding antibodies produced shortly after HIV-1 transmission, we isolated and studied gp41-reactive plasma c...

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Main Authors: Liao, Hua-Xin, Chen, Xi, Munshaw, Supriya, Zhang, Ruijun, Marshall, Dawn J., Vandergrift, Nathan, Whitesides, John F., Lu, Xiaozhi, Yu, Jae-Sung, Hwang, Kwan-Ki, Gao, Feng, Markowitz, Martin, Heath, Sonya L., Bar, Katharine J., Goepfert, Paul A., Montefiori, David C., Shaw, George C., Alam, S. Munir, Margolis, David M., Denny, Thomas N., Boyd, Scott D., Marshal, Eleanor, Egholm, Michael, Simen, Birgitte B., Hanczaruk, Bozena, Fire, Andrew Z., Voss, Gerald, Kelsoe, Garnett, Tomaras, Georgia D., Moody, M. Anthony, Kepler, Thomas B., Haynes, Barton F.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201211/
https://ncbi.nlm.nih.gov/pubmed/21987658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110363
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