Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated

The initial antibody response to HIV-1 is targeted to envelope (Env) gp41, and is nonneutralizing and ineffective in controlling viremia. To understand the origins and characteristics of gp41-binding antibodies produced shortly after HIV-1 transmission, we isolated and studied gp41-reactive plasma c...

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Bibliografski detalji
Glavni autori: Liao, Hua-Xin, Chen, Xi, Munshaw, Supriya, Zhang, Ruijun, Marshall, Dawn J., Vandergrift, Nathan, Whitesides, John F., Lu, Xiaozhi, Yu, Jae-Sung, Hwang, Kwan-Ki, Gao, Feng, Markowitz, Martin, Heath, Sonya L., Bar, Katharine J., Goepfert, Paul A., Montefiori, David C., Shaw, George C., Alam, S. Munir, Margolis, David M., Denny, Thomas N., Boyd, Scott D., Marshal, Eleanor, Egholm, Michael, Simen, Birgitte B., Hanczaruk, Bozena, Fire, Andrew Z., Voss, Gerald, Kelsoe, Garnett, Tomaras, Georgia D., Moody, M. Anthony, Kepler, Thomas B., Haynes, Barton F.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2011
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201211/
https://ncbi.nlm.nih.gov/pubmed/21987658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110363
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