DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

In humans, DOCK8 immunodeficiency syndrome is characterized by severe cutaneous viral infections. Thus, CD8 T cell function may be compromised in the absence of DOCK8. In this study, by analyzing mutant mice and humans, we demonstrate a critical, intrinsic role for DOCK8 in peripheral CD8 T cell sur...

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Autors principals: Randall, Katrina L., Chan, Stephanie S.-Y., Ma, Cindy S., Fung, Ivan, Mei, Yan, Yabas, Mehmet, Tan, Andy, Arkwright, Peter D., Al Suwairi, Wafaa, Lugo Reyes, Saul Oswaldo, Yamazaki-Nakashimada, Marco A., de la Luz Garcia-Cruz, Maria, Smart, Joanne M., Picard, Capucine, Okada, Satoshi, Jouanguy, Emmanuelle, Casanova, Jean-Laurent, Lambe, Teresa, Cornall, Richard J., Russell, Sarah, Oliaro, Jane, Tangye, Stuart G., Bertram, Edward M., Goodnow, Christopher C.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201196/
https://ncbi.nlm.nih.gov/pubmed/22006977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110345
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